269549
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269549
Aldrich
3-Buten-2-one
99%
| Synonym: | Methyl vinyl ketone, Vinyl methyl ketone |
| CAS Number: | 78-94-4 |
| Linear Formula: | CH2=CHCOCH3 |
| Molecular Weight: | 70.09 |
| Beilstein Registry Number: | 506021 |
| EC Number: | 201-160-6 |
| MDL number: | MFCD00008777 |
| PubChem Substance ID: | 24856333 |
Description
| Application | Michael acceptor for thiols1, indoles2 and coumarins3 |
| Substrate used in an iron(II)-catalyzed alkylation of indoles at the C-3 position. Use of excess vinyl ketone provides the 2,3-dialkylated indoles.4 | |
| Packaging | 5, 100, 500 mL in glass btl |
Properties
| vapor density | 1.3 (vs air) |
| vapor pressure | 310 mmHg ( 55 °C) |
| 71 mmHg ( 20 °C) | |
| assay | 99% |
| contains | 0.5% hydroquinone and 0.1% acetic acid as stabilizer |
| expl. lim. | 15.64 % |
| refractive index | n |
| bp | 34 °C/120 mmHg(lit.) |
| density | 0.864 g/mL at 25 °C(lit.) |
Safety
| Hazard Codes | F,T+,N |
| Risk Statements | 11-26/27/28-34-43-50/53 |
| Safety Statements | 16-26-28-36/37/39-45-60-61 |
| RIDADR | UN 1251 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | EM9800000 |
| UEL | 15.64% |
| LEL | 2.14% |
| Flash Point(F) | 20 °F |
| Flash Point(C) | -7 °C |
References
| Cited Reference | 1. Chu, C-M; et al. Tetrahedron Lett. 46, 4971, (2005) |
| 2. Ye, M-C; et al. Synthesis 6, 946, (2006) | |
| 3. Pav'e. G.; et al. Synlett 7, 987, (2003) | |
| 4. Chem. Lett. (Jpn) 36, 50, (2007) | |
| reference | Synth. Commun. 24, 279, (1994) |
| J. Org. Chem. 59, 4162, (1994) | |
| Merck | Merck 13,6155 |
| Beilstein | Beil. 1,IV,3444 |
| Fieser | Fieser 1,697 / Fieser 2,283 / Fieser 5,464 / Fieser 6,407 / Fieser 7,247 / Fieser 10,272 / Fieser 12,329 / Fieser 13,193 |
| Aldrich MSDS 1, 1324:A / Corp MSDS 1 (2), 2463:C / FT-IR 2 (1), 650:C / FT-IR 1 (1), 413:D / FT-NMR 1 (1), 643:C / IR-Spectra (2), 220:B / IR-Spectra (3), 246:D / NMR-Reference 2 (1), 377:B / RegBook 1 (1), 453:A / Sax 6, 552 / Sigma FT-IR 1 (2), 757:C / Structure Index 1, 64:C:8 / Vapor Phase 3, 499:C |
